This briefing note distills key lessons from the review of the LRN1 to help donors, such as FCDO, and other research actors to support locally led research. It serves as a practical guide, offering concrete approaches from the LRN’s experience alongside broader resources on equitable knowledge and evidence production. It highlights the nuances of supporting locally led research in conflict settings – where power dynamics, funding structures, and operational constraints present distinct challenges. This note is not intended to comprehensively address all issues or capture every example of locally led research in diverse contexts and challenging environments.